Alginate hydrogels of varied molecular weight distribution enable sustained release of sphingosine-1-phosphate and promote angiogenesis
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منابع مشابه
Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment.
The objective of this study is to design a drug delivery system (DDS) for the in vivo promotion of macrophage recruitment. As the drug, a water-insoluble agonist of sphingosine-1-phosphate type 1 receptor (SEW2871) was selected. SEW2871 (SEW) was water-solubilized by micelle formation with gelatin grafted by L-lactic acid oligomer. SEW micelles were mixed with gelatin, followed by dehydrotherma...
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Sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR) signaling pathway has been implicated in a variety of pathological processes of ovarian cancer. However, the function of this axis in ovarian cancer angiogenesis remains incompletely defined. Here we provided the first evidence that SphK1/S1P/S1PR1/3 pathway played key roles in ovarian cancer angiogenesis. The expressio...
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Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces release of endothelial cell-specific storage-organelles designated Weibel-Palade bodies (WPBs). S1P-mediated enhancement of endothelial cell barrier function is depende...
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—————————————————————————————————————— macro "Reporter Regions" { /* Instructions * Draw ROI's and save as .zip file * set thresholds for each channel in the variables at the top of the macro * open the .tif image to be analyzed * follow on screen instructions to select the folders to pull the ROI.zip files and where to save the files Macro functions-Changes the background pixels in RFP and GFP...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2017
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36217